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![]() ![]() X-rays show calcium deposits within cartilage and fibro cartilage, mainly in knees, wrists and shoulders. Diagnostic methodsĭiagnosis of CPPD is based on the identification of CPP crystals in synovial fluid by compensated polarized light. ![]() ![]() Mutations in the collagen α-1(II) chain gene ( COL2A1 12q12-13.2), that codes for the major structural protein of cartilage, have been found to cause a particular form of chondrocalcinosis characterized by severe early onset OA, spondylo-epiphysial dysplasia and secondary CPPD. Other familial cases have been linked to mutation in the Tumor Necrosis Factor Receptor Super Family member 11B ( TNFRSF11B) gene coding for osteoprotegerin (OPG) Other causative genes are yet to be determined. Mutations in the ANKH gene (human homologue of progressive ankylosis 5p15.2), encoding a protein involved in cellular inorganic pyrophosphate transport, were identified in some cases of familial CPPD. Very rarely, familial CPPD can be associated with non rheumatological features, such as recurrent infantile seizures as was the case in a British family with CPPD and polyarticular chondrocalcinosis but without structural arthropathy. Chronic inflammatory arthropathy usually affects the knee, wrist, elbow, shoulder and hip, and can induce a severe OA-like arthropathy. The attacks can last from hours (6-24) to days and can induce a limited range of motion. In acute CPP crystal arthritis cases, acute episodes of pain, stiffness, swelling and sometimes ankylosis, can be observed in any joint, the knees or the wrist being the most affected. Generally, it is associated with acute CPP crystal arthritis involving the knees, the wrists, the shoulders, and/or a severe chronic inflammatory arthropathy, mimicking osteoarthritis (OA). Clinical descriptionįamilial CPPD manifests in early adulthood (20-40 years old) and has a variable clinical phenotype. It is rare: about 100 affected families have been identified to date. 1970 211:807–9.Familial calcium pyrophosphate deposition (CPPD) prevalence is unknown. Corticosteroid crystals in synovial fluid. Electron microscopic study of depot corticosteroid crystals with clinical studies after intra-articular injection. Detection of calcium crystals in knee osteoarthritis synovial fluid: a comparison between polarized light and scanning electron microscopy. 1999 58:582–4.įrallonardo P, Oliviero F, Peruzzo L, Tauro L, Scanu A, Galozzi P, Ramonda R, Punzi L. Most calcium pyrophosphate crystals appear as non-birefringent. Analysis for crystals in synovial fluid: training of the analysts results in high consistency. Lumbreras B, Pascual E, Frasquet J, González-Salinas J, Rodríguez E, Hernández-Aguado I. Arthrocentesis and synovial fluid analysis in clinical practice: value of sonography in difficult cases. ![]() Detection and identification of crystals in synovial fluid. Atlas of synovial fluid analysis and crystal identification. The ordinary light microscope: an appropriate tool for provisional detection and identification of crystals in synovial fluid. Prevalence of calcium pyrophosphate and monosodium urate crystals in synovial fluid of patients with previously diagnosed joint diseases. Oliviero F, Scanu A, Galozzi P, Gava A, Frallonardo P, Ramonda R, Punzi L. Update on calcium pyrophosphate deposition. Punzi L, Scanu A, Galozzi P, Luisetto R, Spinella P, Scirè CA, Oliviero F. Monosodium urate and calcium pyrophosphate crystals exhibit opposite colors which allow the analyst to establish their molecular nature. When coupled with a red compensator, polarized light permits distinction between the two types of crystals on the basis of the color produced based on the orientation of the crystal in relation to the optical axis of the compensator. A second polarizing lens placed between the objectives and the oculars serves to detect birefringent crystals which appear bright in a dark background. Using the optical microscope, polarized light is produced by the insertion of a polarizer between the light source and the specimen. The basis of this technique relies on the characteristic property of these crystals to be birefringent, predictably deviating a polarized light plane. In synovial fluid analysis, polarized light represents a fundamental tool in the search for pathogenic monosodium urate and calcium pyrophosphate crystals. Polarized light microscopy allows the detection of birefringent materials in biological samples. ![]() ![]() ![]() Export finished videos using the App Preview share option(1) 4K export requires a Mac from 2011 or later with at least 4 GB RAM.Highlight features with 11 animated titles designed to showcase apps in action.Import iPhone and iPad screen recording videos captured with QuickTime Player.Share any video frame as an imageCreate App Previews for the App Store.Share directly to YouTube and Vimeo at up to 4K resolution.Email videos with Mail Drop when signed in to iCloud.Send your project to Final Cut Pro and take advantage of advanced editing tools, professional effects, third-party plug-ins, and moreShare with friends and family.Choose from 48 fun video and audio effects.Automatically zoom in on faces and glide across panorama photos with the Ken Burns Effect.Stabilize shaky video for a smoother picture that’s easier to watch.Give your video a boost with easy-to-use color controls. ![]() Instantly improve the look and sound of your video using one-click Enhance.Create a soundtrack using built-in music and sound effects, songs from your iTunes library, songs you’ve recorded in GarageBand, and your own narrationFine-tune every clip.Create sophisticated picture-in-picture, side-by-side, and green screen effects.Speed up and slow down the action with fast-forward and slow-motion effects.Enhance your movie by adding titles, transitions, and 3D globes and travel maps.Import movies and trailers created using iMovie on iPhone or iPad to finish them on your Mac.Support for 1080p HD video at 60 frames per second for smoother, more life-like action shots.Edit movies at up to 4K resolution with video from iPhone 6s or later, GoPro, and other Ultra HD cameras on compatible Macs (1).Select the best videos and photos for your trailer with the help of animated drop zonesCreate beautiful 4K and HD movies.Customize movie studio logos, cast names, and credits.Choose from 29 trailer templates with stunning graphics and original scores by some of the world’s top film composers.Background import lets you begin watching and sharing video instantlyMake Hollywood-style trailers.Quickly share a clip or a portion of a clip.See all your video clips and photos organized in one place.You can even start editing movies on an iPhone or iPad, and finish them on a Mac.Browse and share video Browse your video library, share favorite moments, and create beautiful movies that you can edit at resolutions up to 4K. 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![]() ![]() ![]() if you’re not into the ganache topping, feel free to top each mini cheesecake with a dollop of whipped cream and chocolate syrup! That’ll give them an Irish coffee vibe you’re sure to love! When it comes to these mini cheesecakes, I don’t know what I love most. the crunchy chocolate cookie crust, the creamy Baileys cheesecake filling, or the decadent chocolate ganache!!! Thankfully, I don’t have to choose! But do not attempt to thaw cheesecake in the microwave or oven! ![]() To defrost these mini cheesecakes, simply remove from the freezer and thaw in refrigerator overnight. These mini cheesecakes will keep, stored properly in the freezer, for two months. Yes, of course! Simply cool the cheesecakes completely, wrap them tightly in saran wrap, and then place them in a freezer bag. TO MAKE A SILKY SMOOTH BATTER WITHOUT OVERBEATING, BE SURE TO FULLY BLEND THE CREAM CHEESE AND SOUR CREAM BEFORE ADDING THE REMAINING INGREDIENTS.Īnd more good news: no mini cheesecake pan is required for this recipe! I bake these little cuties in a standard cupcake/muffin tin and you can, too! If you have mini cheesecake pans, you’ll need to adjust the cook time depending on the size of your pans. PRO TIP: DO NOT OVER BEAT YOUR CHEESECAKE BATTER! THIS ALLOWS TOO MUCH AIR INTO THE CHEESECAKE BATTER, AND WILL CAUSE THE MINI CHEESECAKES TO EXCESSIVELY RISE IN THE OVEN, AND THEN COLLAPSE WHEN REMOVED.
![]() Guitar chord voicing is very unique depending on guitar construction and is absolutely necessary to reproduce in order to achieve authentically sounding chordal parts. Whether you are playing live or programing a DAW, these techniques are controllable by using special gestures, key switches, key velocity, modulation wheel, sustain pedal, key aftertouch, MIDI CC, DAW parameter automation, and any combinations of these. Techniques and controlĪn authentic sounding guitar part cannot be recorded by using samples on their own, but requires a bunch of guitar-specific techniques, which are simulated in RealLPC. ![]() ![]() Combining a virtual guitar and an FX processor allows you to store a guitar sound and an FX processor preset at the same time, which a real time saver. We recommend to use open-source Guitarix.vst virtual guitar amp as a robust and versatile solution to use these presets. Our experts have thoroughly examined guitar tones used in most popular songs played by greatest guitarists and came up with more than two hundred authentic presets which sound similar to what they heard, ready to be used in your next song. Version 6 supports external guitar FX processors which are important to create a realistic guitar part. RealLPC sample library includes not only sustain sounds, but also other guitar-specific sounds with dynamics and nuances an experienced performer can get from his/her instrument. We've carefully and meticulously recorded high quality dry samples of each fret of all strings directly from Les Paul Custom pick-ups which let you easily create any desired guitar sound using your favorite amplifier simulator. Built-in Song sequencer designed to arrange up to the entire song by simply inserting chord symbols and selecting pre-recorded guitar rhythm patterns.Any guitar performance produced on a MIDI keyboard can be recorded or directly programmed in a MIDI track of any DAW.Intuitive keyboard layout allows Live/MIDI Keyboard performance with numerous articulations, noises, guitar-specific tricks, strumming and finger picking techniques.There are three ways of using RealLPC virtual instrument. ![]() RealLPC covers practically all sounds, articulations, and techniques a professional guitarist can produce on his Les Paul, including mute, bridge mute, harmonics, pinch harmonics, unison bend, strumming, picking, chord chopping, scrapes, and much more. ![]() RealLPC provides incredible playability based on the unique performance modes and easy-to-use keyboard layout as well as the advanced key/pedal/velocity switch system allowing a keyboardist to perform guitar parts with a whole new level of realistic expression. RealLPC - sample-based virtual instrument with an innovative approach to guitar sound modeling and guitar techniques emulating on a standard MIDI keyboard. Gibson's Les Paul Custom, a higher end variation of the Gibson Les Paul guitar has been used by the majority of world famous musicians, spanning generations and genres, such as Wes Montgomery, Al Di Meola, Pat Metheny, Chuck Berry, Jeff Beck, Peter Frampton, The Beatles, The Rolling Stones, Led Zeppelin, B.B.King, Bob Marley, Eric Clapton, Carlos Santana, Gary Moore, Eddie Van Halen and many others. We are proud to present the RealLPC virtual guitar instrument bringing the incomparable Les Paul Custom Guitar sound to your studio. ![]() ![]() ![]() Just Click the Play button and Install the Emulator Plugin to Play.
![]() ![]() We're 99% sure that someone has already asked the same question you have. Also, the search function is your friend. Also, no repeat posts, please.įOR BEGINNERS: You're welcome to post here, following the rules, but you can also head over to /r/snowboardingnoobs to ask questions. SELLING YOUR GEAR? For sale/trade posts are allowed, but all of the relevant information (description, pictures, location, price/terms) must be posted up front. KEEP IT CIVIL: Heated discussions are fine, but hate speech and unwarranted ad hominem attacks may be grounds for a ban. NO MEMES: even if the meme in question shows actual snowboarding, memes are not allowed in the sub. For riding advice and critique, we have a weekly thread where you can submit your video links if you want tips from the community or feedback on your riding. ![]() If you want to submit a picture of your gear or where you ride, please use the Daily Discussion. The general rule is photo and video submissions to /r/snowboarding should be of people actually riding on snowboards. If your thread is removed without explanation, it's most likely because it should be posted there. ![]() Please use the DAILY DISCUSSION thread for general Q&A about gear and skills/technique, and any requests for opinions or help, especially for newbie-related questions. As much as we love helping each other out, we really hate repeating ourselves. Please be sure to read the sidebar before posting. We try to keep /r/snowboarding a friendly place for riders of all skill levels. Shreddit - For snowboarders & those who love snowboards. ![]() ![]() ![]() See the official website for more information on the latter. Type:Rider is available as a mobile game for iOS and Android, as well as a social experience via Facebook, a browser release, and a physical art installation. There's no denying it's a gorgeous game, and it'll definitely bring some awareness to the worlds of typography and the history of written communication. That lack of integration prevents Type:Rider from becoming a truly innovative experience, but the game itself is still surprisingly atmospheric and entertaining. You collect letters and look at fonts while you play, but the real learning aspect takes place via paragraphs of text you unlock and read, stopping the gameplay entirely while you squint at the words. Type:Rider's main gimmick, the inclusion of typeface history, is strangely divorced from the game itself. Grab letters, move blocks around, and bring the glowing orb to the goal so you can take off for some more font fact finding. You'll use these basic abilities to traverse long and varied landscapes, most of which are basic black shapes hovering in front of gorgeous pieces of contextual artwork. ![]() With default, tap the left side of the screen to move left, the right side to move right, and both sides simultaneously to jump. You have three options: tilt, virtual buttons, and the more intuitive default option. ![]() Type:Rider's controls are pretty simple for a mobile game. And you might actually learn something cool along the way! SUVs, family minivans, and other people carriers are concluded as more reliable models because it is associated with family and kids so it will also translate to lesser car wrecks and accidents. As you head through each level, you'll relive that journey one unlockable manuscript at a time. Were approaching the end of April and its that time of the month. May 2017 typerider cross buy drivers This, in return, would mean lower damage and injury claim pay-outs for the insurance company. They're typefaces, each taken from some of the most recognizable fonts throughout history. With Type:Rider, though, those aren't just random shapes you're rolling over and collecting. Taking some visual cues from games like LIMBO, it casts you in the role of two twin orbs traveling through a shadowy world. Director Doug Nichol and Canadian typewriter collector Martin Howard will participate in Q&As after the screenings.Type:Rider is a puzzle platform game as well as an interactive learning experience created by Cosmografik. ![]() Speaking of musicians, there’s a great clip of Bob Dylan composing lyrics on a typewriter, fingers flying and head bopping as though he’s playing a piano.Ĭalifornia Typewriter screens January 11 and 12 at the Bloor Hot Docs cinema in Toronto. Musician/typist John Mayer notes that his old hard drives, while ostensibly preserving data, are really quasi-wastebaskets, since he never looks at them, and they eventually become unreadable by newer generations of computers. ‘Damn fine town’: Tom Hanks sends Toronto fan a selfie and letter, praising the cityĪs long as it doesn’t catch fire, a typewritten note is an excellent way to store data.‘I just like the feel of a book in my hands’: Analog isn’t going anywhere, as long as real things continue to matter.And the Boston Typewriter Orchestra makes music with them, sounding a bit like a performance of Stomp. Artist Jeremy Mayer takes them apart to reassemble into sculptures, and loves the sensual curves to be found in many of their parts. Not all typewriter enthusiasts want to keep the machines in working order. This advertisement has not loaded yet, but your article continues below. ![]() ![]() ![]() If you take medications regularly, check with your doctor to see if they may be contributing to your insomnia. Schedule exercise at least a few hours before bedtime and avoid stimulating activities before bedtime. Regular activity helps promote a good night's sleep. Keep your bedtime and wake time consistent from day to day, including on weekends. The key often lies in changes to your routine during the day and when you go to bed. No matter what your age, insomnia usually is treatable. Talk to your doctor before you take these, as antihistamines may cause side effects, such as daytime sleepiness, dizziness, confusion, cognitive decline and difficulty urinating, which may be worse in older adults.Įxplore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition. Nonprescription sleep medications contain antihistamines that can make you drowsy, but they're not intended for regular use. Prescription sleeping pills can have side effects, such as causing daytime grogginess and increasing the risk of falling, or they can be habit-forming, so talk to your doctor about these medications and other possible side effects. ![]()
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